Experience

CFCS-Consult has been providing regulatory services for industrial chemicals, biocides, and cosmetic ingredients since 2007. We support our clients in achieving compliance with REACH, the Biocidal Products Regulation (BPR), and the EU Cosmetics Regulation by offering expert guidance on hazard and risk assessment, dossier preparation, and regulatory strategy.

Our Accomplishments

Successful submission of numerous REACH Inquiry, Lead, and Member Dossiers.

Management of multiple REACH consortia.

Oversight and monitoring of various experimental studies.

Quality assessments of dossiers with clear improvement recommendations.

Successful regulatory support for biocidal product authorizations.

Preparation of numerous Cosmetic Product safety Assessments.

Study Monitoring Expertise

We have extensive experience in monitoring toxicological and ecotoxicological studies, reproductive toxicity studies, and environmental fate assessments.

Additional Expertise

Acute toxicity studies, including irritation and sensitisation.

Repeated dose toxicity studies (28-day, 90-day studies).

OECD 421/422 (Reproduction/Developmental Toxicity Screening Test).

OECD 414 (Prenatal Developmental Toxicity) in rats and rabbits.

Extended One-Generation Reproductive Toxicity Studies (EOGRTS).

Ecotoxicological studies such as:

  • Acute toxicity in fish, daphnia, and algae
  • OECD 210 (Fish Early Life-Stage Toxicity Test)
  • OECD 211 (Daphnia Reproduction Test)
  • OECD 234 (Fish Sexual Development Test)

Environmental fate studies, including:

  • Biodegradation screening studies
  • Higher-tier degradation studies
  • Adsorption/Desorption studies

Expertise with Complex Substances

We have in-depth experience handling difficult-to-test substances (e.g., UVCBs, poorly soluble substances, and substances with high reactivity), following OECD Guidance Document 23. Our expertise includes designing tailored assessment strategies for challenging test materials.

Read-Across, Weight-of-evidence and Alternative Methods

We have a strong track record in applying alternative approaches to reduce animal testing while ensuring regulatory compliance. Our expertise includes:

Successfully developing and defending numerous Read-Across Justifications accepted by ECHA.

Using QSAR models to predict various toxicological and ecotoxicological endpoints.

Supporting Read-Across Justifications with QSAR data in multiple dossiers.